HRH1 and multiple sclerosis: The contribution of histamine to inflammatory neurological diseases, such as multiple sclerosis, is controversial: although H1R and H2R appear to favour the inflammatory response in brain lesions [64], H3R dampens neuroinflammation, mainly by modulating the production of chemokines and maintaining the integrity of the blood-brain barrier [65] in a murine model of multiple sclerosis, experimental autoimmune encephalomyelitis (EAE).