HRH1 and asthma: H1R antagonism is well known for its beneficial effects in asthma management [86]; however, H2R deficiency or pharmacological blockade worsens lung inflammation in OVA-sensitized mice due to increased activation of iNKT cells, which promotes recruitment of macrophages and neutrophils and production of IL-4, IL-17, and IFN-γ by T cells [13].