We previously showed that a human glioblastoma xenograft with <20% nectin-1 expression was less sensitive to infection and killing by HSV-1 than tumors with higher expression, and other groups determined that nectin-1 predicted oncolysis by HSV-1 in squamous cell carcinoma, thyroid cancer, and EBV-associated lymphoproliferative disease25–28. The gene discussed is NECTIN1; the disease is thyroid cancer.