While nectin-1 predicts sensitivity in some tumor types, expression levels do not correlate with oHSV sensitivity in all tumor types; sensitivity of neuroblastoma cell lines to γ134.5-deleted HSV1716 was independent of nectin-1 or other known entry molecules such as nectin-2, herpes virus entry mediator (HVEM), or 3-OS heparin sulfate30. This evidence concerns the gene TNFRSF14 and neuroblastoma.