NECTIN1 and neoplasm: Pediatric tumor X21415, which had the highest nectin-1 expression of the four tumors, was the most sensitive tumor; mean and median survival time in mice bearing intracranial tumors were significantly prolonged after treatment with a single 1 × 107 PFU dose of M002 (mean 81.0 ± 8.2 days; p = 0.0006) or G207 (mean 67.3 ± 6.5 days; median 64.0 ± 6.2; p = 0.004) compared to saline (mean 42.9 ± 3.1 days; median 41.0 ± 3.1) (Fig. 4A).