TJP1 and metabolic process: Importantly, we have demonstrated that mice treated with GOP were characterized by a reduction in intestinal permeability (high FITC-dextran and DAO concentrations in plasma) and metabolic endotoxaemia (high LPS concentration in plasma) induced by irradiation, which was proposed to be associated with the disruption of the crucial tight junction proteins, ZO-1 and occluding25.