HSP90AA1 and non-small cell lung carcinoma: In summary, the present study demonstrates that NCT-50 exhibits significant cytotoxic and antiangiogenic activities in NSCLC cells by suppressing Hsp90 function through directly binding to the C-terminal ATP-binding pocket of Hsp90, suggesting that NCT-50 can be considered a novel hit compound to further develop as an anticancer Hsp90 inhibitors.