MiRNA-378 promoted BM in NSCLC by increasing the expression levels of matrix metalloproteinase 7 (MMP-7), MMP-9, and vascular endothelial growth factor (VEGF) and by decreasing the levels of suppressor of fused homolog, all of which are key genes that are involved in angiogenesis and invasion of the extracellular matrix27. This evidence concerns the gene VEGFA and non-small cell lung carcinoma.