In addition to these alterations, SCLCs also show alterations in pathways that regulate neuroendocrine differentiation (such as NOTCH signaling) and amplifications in oncogenes such as SOX2, MYC, MYCL, and MYCN. While the genomic landscape of treatment-naive SCLC has been well described by different groups, very few samples profiled to date have been obtained from patients with relapsed disease in these studies3,7–9. The gene discussed is MYC; the disease is small cell lung carcinoma.