The results show that pro‐IL‐1β levels in nAMD, polypoidal choroidal vasculopathy (PCV), and Eales’ disease vitreous samples were significantly elevated, and IL‐1β expression in nAMD, PCV, Eales’ disease, and RVO vitreous samples was significantly elevated when compared with the control group. Here, IL1B is linked to Polypoidal choroidal vasculopathy.