However, while IL-6 deficiency ameliorates DEN-induced HCC in lean and obese mice, inactivation of IL-6 receptor alpha (IL-6Rα) reduces DEN-induced tumor burden only in lean mice, suggesting a compensatory overlapping signaling cascade in obese IL-6Rα-deficient mice [11], [23]. The gene discussed is IL6R; the disease is hepatocellular carcinoma.