Laparoscopic metabolic surgery also be considered to be an option to treat T2MD in patients with BMI 30.0–34.9 kg/m2 or 27.5–32.4 kg/m2 in Asian descent, and inadequately controlled hyperglycemia despite optimal medical treatment by either oral or injectable insulin during Diabetes Surgery Summit II [54]. This evidence concerns the gene INS and Hyperglycemia.