RUNX2 and head and neck squamous cell carcinoma: For instance, the Runt related transcription factor 2 (RUNX2) gene facilitates autophagy in metastatic cancer breast cells by increasing acetylation of α-tubulin sub-units of microtubules [42], and autophagic cell death in head and neck squamous cell carcinoma is mediated by DUSP4 (Dual Specificity Phosphatase 4) [43].