The proportion of some comorbidities were even higher in 2012 than in 2006: 17.6% of patients had a respiratory disease in 2012 vs. 14.1% in 2006 (p = 0.001), and 25.5% had serum albumin concentration &lt; 30 g/l in 2012 vs. 19.6% in 2006, p = 0.004. The gene discussed is ALB; the disease is respiratory system disorder.