In this study, we found that, compared to the control SC group, the IR animals exhibited increased heart failure biomarkers (BNP, ß-MHC) and sarcomere length while they had decreased levels of myocardial integrity biomarkers (connexin43, mitochondrial cytochrome-C, α-MHC, BMP-2, Smad1/5). Here, BMP2 is linked to heart failure.