In this study, we found that, compared to the control SC group, the IR animals exhibited increased heart failure biomarkers (BNP, ß-MHC) and sarcomere length while they had decreased levels of myocardial integrity biomarkers (connexin43, mitochondrial cytochrome-C, α-MHC, BMP-2, Smad1/5). This evidence concerns the gene SMAD1 and heart failure.