Our results indicate that TRPC6 expression is up-regulated in ER+ and triple negative breast cancer cell lines, where TRPC6 interacts with the most prominent Orai isoform for SOCE, Orai1 in MDA-MB-231 cells and Orai3 in MCF7, as previously described [35]. The gene discussed is ORAI1; the disease is triple-negative breast carcinoma.