ORAI1 and breast carcinoma: As shown in Figure S2, expression of the TRPC6dn significantly attenuated the interaction of TRPC6 with the Orai channels in MCF7 and MDA-MB-231 cells (p < 0.05; n = 4), thus suggesting that TRPC6 channel function is essential for its interaction with Orai3 in MCF7 and Orai1 in MDA-MB-231 breast cancer cells.