As SOCE in breast cancer cells depends on the Orai channels, and the extent of SOCE inhibition in cells transfected with shTRPC6 in our hands was similar to that reported by Motiani and coworkers after Orai1 and Orai3 knockdown in MDA-MB-231 and MCF7, respectively [35], we hypothesized that TRPC6 might be regulating the Orai channels rather than playing a major role in the conduction of Ca2+ entry during SOCE. The gene discussed is TRPC6; the disease is breast cancer.