IFN-α pre-stimulated NK cells have been reported to kill HCV-infected hepatoma cells, which suggests that the modulation of cytokine production such as neutralizing IL-10 or adding IL-12 or IL-21 in coculture of NK cells and HCV-infected hepatoma cells could be considered as an immunotherapeutic approach against HCV infection [21]. This evidence concerns the gene IL10 and hepatocellular carcinoma.