Perinuclear aggresomes, commonly arising in vitro in cells under various stressors [70] or in vivo in several degenerative diseases [88,89], are cytoplasmic bodies characterized by a variety of aggregated, denatured, mutated, and ubiquitinated proteins, together with the p62/SQSTM1 protein, with or without cytosolic or ER-resident chaperon molecules, as well as proteasomes [72,90,91]. This evidence concerns the gene SQSTM1 and neurodegenerative disease.