For example, TOP2B is required for most etoposide-induced chromosome breaks at the MLL/KMT2A and RUNX1 loci using DNA FISH in a human cell line model [82,83], top2b is required for efficient etoposide-induced recombination in a plasmid integration assay [84] and TOP2B is implicated in androgen-induced chromosome rearrangements in prostate cancer [85]. Here, KMT2A is linked to prostate cancer.