KMT2A and leukemia: These t-AML cases often exhibit one of a set of recurrent chromosome translocations that drive the development of the leukaemia, most frequently involving the MLL/KMT2A gene at 11q23, t(15,17)(PML-RARA), t(8,21)(RUNX1-ETO), or inv(16) (CBFB-MYH11) [79,81].