Dobutamine, a sympathomimetic amine used as an inotropic agent in heart failure, trough Gs coupling, promotes YAP phosphorylation on S127 site through PKA signaling and so YAP cytoplasmatic retention, confirming in vitro YAP-TEAD transcriptional activity suppression likely involved in F-actin regulation through Rho GTPases, as well as other GPCRs [25]. Here, YAP1 is linked to heart failure.