This pathway promotes YAP dephosphorylation, in PDAC (pancreatic ductal adenocarcinoma) cells through PI3K (phosphatidylinositol-4,5-bisphosphate 3-kinase) activation and its downstream effectors, mTOR (mammalian target of rapamycin) signaling pathway, and GSK3β [42] by impairing the PI3K-AKT pathway such as in the case of statins and kinases inhibitors. This evidence concerns the gene MTOR and pancreatic ductal adenocarcinoma.