FLT3 and NPM1 mutations were restricted to cases with AML NOS and MDS/MPN (FLT3:c.2134A>T p.R712W, FLT3:c.2812_2820dupAATTTGACT p.N938_T940dupNLT, FLT3:c.2503G>T p.D835Y, NPM1: c.393_395dupGGA p.E131dup). This evidence concerns the gene FLT3 and acute myeloid leukemia.