ASXL1 (additional sex combs like 1) is a gene that is mutated in a number of hematological neoplasms including Myelodysplastic Syndrome (MDS), Acute Myeloid Leukemia (AML), Myeloproliferative Neoplasms (MPN), Chronic Myelomonocytic Leukemia (CMML) and Chronic Myeloid Leukemia (CML). Here, ASXL1 is linked to hematopoietic and lymphoid system neoplasm.