Interestingly, our proteomics analysis of the T246M rodent cerebellum revealed a decrease in Bag3 protein levels (S2 Fig, S1 Table), so one distinct possibility for the pathology associated with SCAR16 may be a disruption in either the macro autophagy or chaperone-mediated autophagy pathways, rendering cells susceptible to proteinopathies. The gene discussed is STUB1; the disease is proteostasis deficiencies.