Expression of mRNA encoding Aurora A and B is higher in glioma than in normal brain tissue.37, 38, 39, 40 In addition, higher expression of Aurora A mRNA or protein is associated with poor survival of glioblastoma patients.40, 41, 42 Expression of Aurora B protein is more common in patients with short survival times than in those with long survival times.43 Therefore, several trials have attempted to use an Aurora kinase inhibitor to treat glioblastoma. This evidence concerns the gene AURKB and central nervous system cancer.