Indeed, RPPA data revealed an enrichment of cell cycle‐related genes including CDC25C and PLK1 in proteins downregulated by metformin, echoing a previous report showing selective translational inhibition of cell cycle regulators such as cyclin E2 and ODC1 by metformin in breast cancer cells (Larsson et al., 2012). This evidence concerns the gene CCNE2 and breast carcinoma.