A very recent study, based on granulation tissue biopsies in patients with T2DM, showed that mRNA levels of several growth factors, such as VEGF and TGF-β1, were significantly increased, while the levels of matrix metalloproteinases (MMP-1 and MMP-9) and TNFα were significantly downregulated after NPWT [20]. This evidence concerns the gene MMP1 and type 2 diabetes mellitus.