Although some work has been carried out in this area, information remains limited and results are somewhat contradictory, with Park et al. (2014) and Neumann et al. (2012) demonstrating microsatellite stability with its implicit accompanying proficient DNA mismatch repair system in CRC being associated with high CD133, and Huh et al. (2010) the reverse. This evidence concerns the gene PROM1 and colorectal carcinoma.