Although when expressed, CD133 decorated the luminal surface of the tumor glands when the glandular structures could be clearly deciphered (Fig. 1B), tumors with poor differentiation commonly demonstrated CD133 as tiny blobs which probably represent abortive glands, in the tumor cellular cytoplasm (Fig. 1C) (Mia-Jan et al., 2013). Here, PROM1 is linked to neoplasm.