Since we found that RSV alone or in combination with exercise positively affects these parameters, in the present work we hypothesized that increased levels of oxidative stress, inflammation and apoptosis, which were seen in NAFLD rats in our previous study (Hajighasem, Farzanegi & Mazaheri, 2018), may be due to decreased expression of Lxr, Fxr and Sirt1. Therefore, we decided to consider this correlation in NAFLD rats and also the effects of treatments with RSV and exercises on these correlations. Here, NR1H4 is linked to metabolic dysfunction-associated steatotic liver disease.