INS and neoplasm: We also detected one region located at 51.5 Mb in chromosome 5 with high selection signal (FST = 0.574986) that contained gene AKT1. AKT1 (protein kinase B, PKB) is a serine/threonine kinase that plays a critical role in regulating cell survival, insulin signaling, angiogenesis and tumor formation [27–29].