EGFR and non-small cell lung carcinoma: Our findings, which suggest an intriguing possibility that failure of EGFR inhibitors to inhibit GLUT1-mediated glucose metabolism in EGFR-wt NSCLC cells might be a key mechanism behind their resistance to EGFR inhibitors, imply that concurrent inhibition of GLUT1 may be a rational and viable approach to overcoming the resistance of EGFR-wt NSCLC to EGFR inhibitors.