EGFR and non-small cell lung carcinoma: Understanding the mechanisms behind the resistance of NSCLCs without activating EGFR mutations to EGFR inhibitors is therefore considered crucial to further improve the efficacy of EGFR inhibitors in NSCLC, but the details as to how the absence of such mutations render NSCLC resistant to EGFR inhibitors still remain largely unknown [8, 9, 10].