GDNF has been shown to enhance the migration of colon cancer cells by increasing vascular endothelial growth factor (VEGF)/VEGF receptor interactions, which are mainly regulated by the p38, phosphatidylinositol 3-kinase/Akt, and hypoxia-inducible factor 1α signaling pathways [30]. The gene discussed is AKT1; the disease is malignant colon neoplasm.