These genes showing lower methylation included WNT1, OTX2, GDNF, and FGFR1. The proposed mechanisms for the oncogenic function of OTX2 include transactivation of cell cycle genes and induction of the MYC oncogene, which play key roles in tumor maintenance in some medulloblastomas [27, 28]. Here, WNT1 is linked to medulloblastoma.