FAP and neoplasm: In intermediate methylation marker genes, the average β-value of FAP IME neoplasms was 0.22 ± 0.01, which was significantly lower than that of sporadic IME CRC (0.35 ± 0.00, P = 6 × 10−29, t-test) and rather similar to that of sporadic LME CRC (0.15 ± 0.00; Figure 4).