OTX2 and neoplasm: Although high methylation marker genes should be methylated only in HME CRC samples, and their average β-value in IME CRC samples was < 0.2, β-values were even lower in IME FAP neoplasms than in sporadic IME CRC, e.g., WNT1 (P = 2 × 10−6) and OTX2 (P = 0.001), as shown in Figure 5.