Whereas sporadic CRC is known to be stratified into several molecular subtypes with/without these mutations and the tumorigenic pathway is more complicated [8, 10, 21], accumulation of DNA hypermethylation and KRAS mutation was demonstrated to be completed by adenoma stage in IME neoplasms [23], in good agreement with adenoma-carcinoma sequence. The gene discussed is KRAS; the disease is adenoma.