Although our results demonstrate that ALN can affect cofilin and cell invasion/migration in vitro at very low concentrations and that systemic ALN treatment can decrease cofilin level in xenografts and also growth rate and metastasis in an orthotopic tumor model [17], therapeutic exploitation of effects of ALN and possible other N-BP on prostate tumors might be a challenge. The gene discussed is CFL1; the disease is prostate neoplasm.