Mutant BRAF V600E was identified in tumor tissue (fresh biopsy n= 20, FFPE n= 3) in 5% of non-melanoma CoPPO patients (23/455 patients) including colorectal (n=16), bile duct (n=4), lung (Non-Small Cell Lung Cancer, NSCLC) (n=2), and pancreatic cancers (n=1) (Figure 1). Here, BRAF is linked to familial pancreatic carcinoma.