IL-6 upregulates the expression of MMPs (1, 2, and 9) [14, 15], thereby increasing cell migration and tumor metastasis; while IL-8 has been implicated in the upregulation of MMP 2 [13] and mediation of MMP-9 release [16], which correlates with high-grade and invasive tumors [17]. This evidence concerns the gene CXCL8 and neoplasm.