Immunohistochemistry staining with a pan-TRK antibody (monoclonal rabbit antibody EPR17341, Abcam) did not detect TRK expression.12 The tumour had a pathogenic TP53 missense variant c.422G>A (p.Cys141Tyr), as well as somatic copy neutral loss of heterozygosity on chromosome 17, resulting in clonal biallelic loss of TP53, plus hemizygous loss of 9p and 18q, three copies of chrX, and biallelic focal deletion of CDKN2A/B. The gene discussed is TP53; the disease is neoplasm.