How Numb inhibits the signalling activity of Notch has been testified for a long time, which may directly or indirectly inhibit Notch.25 Using quantitative real-time PCR, we found that Numb expression in colon cancer cells transfected with miR-142-3p was significantly decreased compared with colon cancer cells transfected with a negative control. The gene discussed is NUMB; the disease is malignant colon neoplasm.