For example, depletion of IGF2BP1 inhibited proliferation and induced apoptosis of liver cancer cells in vitro, and suppressed tumor growth of murine xenograft in vivo [36]; IGF2BP1 was commonly up-regulated both in human cervical cancer tissues and cell lines, and was identified as a direct target of a tumor suppressive miRNA-miR-140-5p [37]. This evidence concerns the gene IGF2BP1 and liver cancer.