IGF2BP1 and neoplasm: Meanwhile, there are still some limitations need further solving: At first, the follow-up time of the clinical cohort used in this study was relatively short, which may lead to some unexpected results, for example, tumor grade was not identified as a prognostic factor in our survival analysis; Secondly, why miR-150-IGF2BP1 axis was dysregulated in osteosarcoma; Thirdly, whether there are other mechanism for the involvement of miR-150-IGF2BP1 axis in osteosarcoma.