GH1 and brain neoplasm: Similarly, only one intracranial hemorrhage and two unspecified stroke cases were identified in 1024 adult patients with childhood-onset GHD who received GH as children and were subsequently followed up in the Hypopituitary Control and Complications Study; all three patients had underlying risk factors: two patients with a history of brain tumor, surgery, and radiotherapy and one with a history of meningocele surgery (41).