NUCLEOLIN and ocular melanoma: We assessed the distribution of the nuclear protein nucleolin, which is known to act as a histone chaperone [57], and found that while there did not appear to be any effect of the shock wave (Fig. 2c), there was a significant drop in the number of nucleolin spots per nuclei in OM and OM + SW when compared to GM and GM + SW at 24 h (Mean ± SD: GM = 2.74 ± 1.4, GM + SW = 2.99 ± 1.4, OM = 2.49 ± 1.2, OM + SW = 2.22 ± 1.1).