Previous studies have shown that the protection rates against RV challenge correlate positively with HRV-specific IFN-γ producing T cell responses, but negatively with those of inducible Treg (CD4+CD25−Foxp3+) cells which are derived from naïve CD4+CD25− T cells in response to rotavirus infection and vaccination [41], [42], [43], [44]. Here, CD4 is linked to Rotavirus infection.