Extracellular (ex)-miRNAs have thus been investigated as minimally invasive biomarkers for DMD, an unmet clinical need.18, 19 As such, myomiRs have been found to be highly enriched in dystrophic serum.9, 20, 21, 22 Importantly, therapeutic restoration of dystrophin protein expression by exon skipping (using both virus-encoded U1/U7-small nuclear RNA [snRNA] and non-viral peptide-phosphorodiamidate morpholino oligonucleotide [PPMO] approaches) induced a restoration of circulating ex-myomiRs toward wild-type levels in dystrophic mice.9, 20, 22, 23. Here, DMD is linked to Duchenne muscular dystrophy.