Since vitamin C and E supplementation also reduced cholesterol levels transported in apo B-containing lipoproteins, attenuation of this proatherogenic dyslipidemia may have played a role in reducing atherogenesis and increasing lifespan in atherogenic diet-fed SR-B1 KO/ApoER61h/h mice, a known murine model of severe dyslipidemia, progressive atherosclerosis, coronary heart disease and premature death. The gene discussed is APOB; the disease is coronary artery disorder.