This study shows that preventive vitamin C and E supplementation leads to protective HDL remodeling, increased antioxidant HDL protein content and improved HDL antioxidant activity as well as attenuated atherogenic apo B-48-dependent hyperlipidemia and reduced inflammation in atherogenic diet-fed SR-B1 KO/ApoER61h/h mice. The gene discussed is SCARB1; the disease is hyperlipidemia.