Increased lifespan induced by vitamin C and E pre-treatment in atherogenic diet-fed SR-B1 KO/ApoER61h/h mice may be explained by reduced levels of atherogenic lipoproteins and improved intermediate metabolic biomarkers linked to oxidative stress and inflammation together with atheroprotective HDL remodeling, which led to reduced atherosclerosis progression with delayed fatal ischemic complications due to coronary heart disease. Here, SCARB1 is linked to coronary artery disorder.