PIK3R1 and Familial prostate cancer: Furthermore, mutation profile detected in organoid lines overlaid the prevalent mutations in prostate cancer, such as mutations in TP53, forkhead box A1, phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1), alpha thalassemia/mental retardation syndrome X-linked, checkpoint kinase 2, KDM4C, KDM4D, and MLL2 [37].