A diversity of characteristic copy number alterations (CNAs) in prostate cancer were detected in the prostate tumoroid lines, including deletions of SHQ1, transmembrane protease, serine 2/erythroblast transformation-specific-related gene and phosphatase and tensin homolog (PTEN) as well as the amplification of androgen receptor (AR) [37]. Here, PTEN is linked to Familial prostate cancer.