Within the 309-kb significant region were four annotated genes: Mindbomb E3 Ubiquitin Protein Ligase 1 (mib1mib1), Abhydrolase Domain Containing 3 (abhd3), Growth regulation by estrogen in breast cancer-like 1, (greb1L), and Rho Associated Coiled-Coil Containing Protein Kinase 1, (rock1), as well as two intergenic regions (Fig. 2a). This evidence concerns the gene ROCK1 and cancer.