Antibodies against the juxtaparanodal protein CASPR2 are associated with a variety of movement disorders including neuromyotonia, chorea, ataxia, and a syndrome of orthostatic myoclonus.3, 65 Many of these typically occur in the context of an encephalopathy that is similar to that associated with LGI1 antibodies. Here, CNTNAP2 is linked to Encephalopathy.