NGS-based findings confirmed the role of more well-known genes (BRAF, NRAS, TP53, CDKN2A, PTEN, MAP 2K1-2, KIT, and RB1) and recently identified genes (NF1, ARID2, PPP6C, RAC1, DDX3X, and IDH1) in melanoma. The gene discussed is ARID2; the disease is melanoma.