The presence of ApaI, TaqI and BsmI VDR polymorphisms could impede the interaction between vitamin D and VDR, resulting in ineffective vitamin D-VDR complex, impaired VDR-mediated transcription, decreased activity of vitamin D related signaling pathways, transition to a Th1 polarization, and consequently, to a more progressive form of liver cirrhosis (Fig. 2). The gene discussed is VDR; the disease is cirrhosis of liver.