The relationship between liver fibrosis progression and the presence of VDR polymorphisms (ApaI, TaqI and BsmI) has been investigated, indicating that in PBC patients, BsmI and TaqI were associated with progressive cirrhosis10 and in NAFLD patients, VDR mRNA expression and profibrogenic genes were significantly affected by BsmI polymorphism18. This evidence concerns the gene VDR and Hepatic fibrosis.