As shown in Fig. 3C, and Supplementary Table S3, all the T3DE-miRNAs were predicted to have a role in the selected processes leading to adverse remodeling (“apoptosis”, “p53 signaling”, “Tgfb signaling” and “ECM receptor pathways”), and heart disease evolution (“hypertrophic cardiomyopathy” and “dilated cardiomyopathy”). This evidence concerns the gene TP53 and hypertrophic cardiomyopathy.