In another RCT examining the effect of a lifestyle intervention including two phone dietary consultations and twice-weekly exercise groups on glucose metabolism in 606 healthy first time pregnant women with pre-pregnant BMI > = 19 kg/m2, the intervention failed to improve glucose levels or reduce GDM incidence but was able to reduce GWG at term as well as the insulin and leptin levels20. This evidence concerns the gene INS and gestational diabetes.