Regarding expressions of hepatic bile acid and bilirubin-metabolizing/detoxifying enzymes (cytochrome P450 family 2 subfamily b [CYP2B10], sulfotransferase family 2A [SULT2A1], and UDP glucuronosyltransferase family 1 member A1 [UGT1A1]), Figure 3 showed a significant decrease (P<0.05) in mRNA expressions of CYP2B10 and SULT2A1 in cholestatic mice compared with control group, while the expression of UGT1A1 revealed no change in the LCA model of cholestasis. Here, UGT1A1 is linked to cholestasis.