CYP2B6 and Leber congenital amaurosis: Regarding expressions of hepatic bile acid and bilirubin-metabolizing/detoxifying enzymes (cytochrome P450 family 2 subfamily b [CYP2B10], sulfotransferase family 2A [SULT2A1], and UDP glucuronosyltransferase family 1 member A1 [UGT1A1]), Figure 3 showed a significant decrease (P<0.05) in mRNA expressions of CYP2B10 and SULT2A1 in cholestatic mice compared with control group, while the expression of UGT1A1 revealed no change in the LCA model of cholestasis.