Using a linear model controlling for cancer type, we found that the 6 individuals with germline:somatic MMR alterations were diagnosed on average 14 years earlier (p = 0.0041) and have 2.8 fold higher somatic MSI (p = 3.95e−15) than individuals with any other type of MMR pathway alteration (Fig. 2b, Additional file 1: Tables S5, S6). This evidence concerns the gene MRC1 and cancer.