In our previous study (GSE52068), we identified four substantially hypermethylated probes for TIPE3 (cg05905176, cg00063471, cg18588323 and cg06813578) in NPC tissues compared to the NPEC tissues (Fig. 1b), which were confirmed by another published microarray data from Hong Kong (GSE62336 [15]), except for cg00063471 (Fig. 1c). The gene discussed is TIPE3; the disease is nasopharyngeal carcinoma.