In this study, through analyzing our previous methylation microarray data, numerous aberrant methylated CpG sites were found in NPC tissues, among which the TIPE3 was found to be remarkably hypermethylated, which was also observed in several human solid cancers in TCGA dataset, such as BRCA, HNSC, and CESC. Here, TIPE3 is linked to cervical squamous cell carcinoma.