EGFR and lung carcinoma: Huang and colleagues carried out immunostaining analysis of exosomes of NSCLC tissues and chronic pneumonia tissues, and found that 80% of the NSCLC specimens were EGFR positive on the surface of the exosomes, while only 2% of the chronic pneumonic tissues were EGFR positive, which suggested that exosomal EGFR protein could be used as a biomarker for differential diagnosis of lung cancer [41] and indicated that gene detection could be further carried out to provide a molecular basis for targeted therapy.