It is important to note that the alleles that showed a positive and significant correlation with AD (HLA-A*29, HLA-B*08, HLA-B*38, HLA-DRB1*01 e HLA-DRB1*03) presented a correlation coefficient for interpolation ranging from 0.513 to 0.982 and maximum RMSD of 0.017 (Additional file 9). The gene discussed is HLA-DRB1; the disease is Alzheimer disease.